Small Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment (2024)

Kirbas Cilingir, E., Besbinar, O., Giro, L., Bartoli, M., Hueso, J. L., Mintz, K. J., Aydogan, Y., Garber, J. M., Turktas, M., Ekim, O., Ceylan, A., Unal, M. A., Ensoy, M., Arı, F., Ozgenç Çinar, O., Ozturk, B. I., Gokce, C., Cansaran-Duman, D., Braun, M., ... Leblanc, R. M. (2024). Small Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment. Small, 20(18), Article 2309283. https://doi.org/10.1002/smll.202309283

Kirbas Cilingir, Emel ; Besbinar, Omur ; Giro, Linda et al. / Small Warriors of Nature : Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment. In: Small. 2024 ; Vol. 20, No. 18.

@article{fab22d9b442b41c8b13da53bbd9882f1,

title = "Small Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment",

abstract = "The appeal of carbon dots (CDs) has grown recently, due to their established biocompatibility, adjustable photoluminescence properties, and excellent water solubility. For the first time in the literature, copper chlorophyllin-based carbon dots (Chl-D CDs) are successfully synthesized. Chl-D CDs exhibit unique spectroscopic traits and are found to induce a Fenton-like reaction, augmenting photodynamic therapy (PDT) efficacies via ferroptotic and apoptotic pathways. To bolster the therapeutic impact of Chl-D CDs, a widely used cancer drug, temozolomide, is linked to their surface, yielding a synergistic effect with PDT and chemotherapy. Chl-D CDs' biocompatibility in immune cells and in vivo models showed great clinical potential.Proteomic analysis was conducted to understand Chl-D CDs' underlying cancer treatment mechanism. The study underscores the role of reactive oxygen species formation and pointed toward various oxidative stress modulators like aldolase A (ALDOA), aldolase C (ALDOC), aldehyde dehydrogenase 1B1 (ALDH1B1), transaldolase 1 (TALDO1), and transketolase (TKT), offering a deeper understanding of the Chl-D CDs' anticancer activity. Notably, the Chl-D CDs' capacity to trigger a Fenton-like reaction leads to enhanced PDT efficiencies through ferroptotic and apoptotic pathways. Hence, it is firmly believed that the inherent attributes of Chl-CDs can lead to a secure and efficient combined cancer therapy.",

keywords = "carbon dots, chemotherapy, combined cancer treatment, fenton triggered reactive oxygen species production, photodynamic therapy, red emissive nanomaterials",

author = "{Kirbas Cilingir}, Emel and Omur Besbinar and Linda Giro and Mattia Bartoli and Hueso, {Jose L.} and Mintz, {Keenan J.} and Yagmur Aydogan and Garber, {Jordan M.} and Mine Turktas and Okan Ekim and Ahmet Ceylan and Unal, {Mehmet Altay} and Mine Ensoy and Fikret Arı and {Ozgen{\c c} {\c C}inar}, Ozge and Ozturk, {Berfin Ilayda} and Cemile Gokce and Demet Cansaran-Duman and Markus Braun and Josef Wachtveitl and Jesus Santamaria and Delogu, {Lucia Gemma} and Alberto Tagliaferro and A{\c c}elya Yilmazer and Leblanc, {Roger M.}",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley-VCH GmbH.",

year = "2024",

month = may,

day = "2",

doi = "10.1002/smll.202309283",

language = "British English",

volume = "20",

journal = "Small",

issn = "1613-6810",

publisher = "Wiley-VCH Verlag",

number = "18",

}

Kirbas Cilingir, E, Besbinar, O, Giro, L, Bartoli, M, Hueso, JL, Mintz, KJ, Aydogan, Y, Garber, JM, Turktas, M, Ekim, O, Ceylan, A, Unal, MA, Ensoy, M, Arı, F, Ozgenç Çinar, O, Ozturk, BI, Gokce, C, Cansaran-Duman, D, Braun, M, Wachtveitl, J, Santamaria, J, Delogu, LG, Tagliaferro, A, Yilmazer, A & Leblanc, RM 2024, 'Small Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment', Small, vol. 20, no. 18, 2309283. https://doi.org/10.1002/smll.202309283

Small Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment. / Kirbas Cilingir, Emel; Besbinar, Omur; Giro, Linda et al.
In: Small, Vol. 20, No. 18, 2309283, 02.05.2024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Small Warriors of Nature

T2 - Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment

AU - Kirbas Cilingir, Emel

AU - Besbinar, Omur

AU - Giro, Linda

AU - Bartoli, Mattia

AU - Hueso, Jose L.

AU - Mintz, Keenan J.

AU - Aydogan, Yagmur

AU - Garber, Jordan M.

AU - Turktas, Mine

AU - Ekim, Okan

AU - Ceylan, Ahmet

AU - Unal, Mehmet Altay

AU - Ensoy, Mine

AU - Arı, Fikret

AU - Ozgenç Çinar, Ozge

AU - Ozturk, Berfin Ilayda

AU - Gokce, Cemile

AU - Cansaran-Duman, Demet

AU - Braun, Markus

AU - Wachtveitl, Josef

AU - Santamaria, Jesus

AU - Delogu, Lucia Gemma

AU - Tagliaferro, Alberto

AU - Yilmazer, Açelya

AU - Leblanc, Roger M.

N1 - Publisher Copyright:© 2024 Wiley-VCH GmbH.

PY - 2024/5/2

Y1 - 2024/5/2

N2 - The appeal of carbon dots (CDs) has grown recently, due to their established biocompatibility, adjustable photoluminescence properties, and excellent water solubility. For the first time in the literature, copper chlorophyllin-based carbon dots (Chl-D CDs) are successfully synthesized. Chl-D CDs exhibit unique spectroscopic traits and are found to induce a Fenton-like reaction, augmenting photodynamic therapy (PDT) efficacies via ferroptotic and apoptotic pathways. To bolster the therapeutic impact of Chl-D CDs, a widely used cancer drug, temozolomide, is linked to their surface, yielding a synergistic effect with PDT and chemotherapy. Chl-D CDs' biocompatibility in immune cells and in vivo models showed great clinical potential.Proteomic analysis was conducted to understand Chl-D CDs' underlying cancer treatment mechanism. The study underscores the role of reactive oxygen species formation and pointed toward various oxidative stress modulators like aldolase A (ALDOA), aldolase C (ALDOC), aldehyde dehydrogenase 1B1 (ALDH1B1), transaldolase 1 (TALDO1), and transketolase (TKT), offering a deeper understanding of the Chl-D CDs' anticancer activity. Notably, the Chl-D CDs' capacity to trigger a Fenton-like reaction leads to enhanced PDT efficiencies through ferroptotic and apoptotic pathways. Hence, it is firmly believed that the inherent attributes of Chl-CDs can lead to a secure and efficient combined cancer therapy.

AB - The appeal of carbon dots (CDs) has grown recently, due to their established biocompatibility, adjustable photoluminescence properties, and excellent water solubility. For the first time in the literature, copper chlorophyllin-based carbon dots (Chl-D CDs) are successfully synthesized. Chl-D CDs exhibit unique spectroscopic traits and are found to induce a Fenton-like reaction, augmenting photodynamic therapy (PDT) efficacies via ferroptotic and apoptotic pathways. To bolster the therapeutic impact of Chl-D CDs, a widely used cancer drug, temozolomide, is linked to their surface, yielding a synergistic effect with PDT and chemotherapy. Chl-D CDs' biocompatibility in immune cells and in vivo models showed great clinical potential.Proteomic analysis was conducted to understand Chl-D CDs' underlying cancer treatment mechanism. The study underscores the role of reactive oxygen species formation and pointed toward various oxidative stress modulators like aldolase A (ALDOA), aldolase C (ALDOC), aldehyde dehydrogenase 1B1 (ALDH1B1), transaldolase 1 (TALDO1), and transketolase (TKT), offering a deeper understanding of the Chl-D CDs' anticancer activity. Notably, the Chl-D CDs' capacity to trigger a Fenton-like reaction leads to enhanced PDT efficiencies through ferroptotic and apoptotic pathways. Hence, it is firmly believed that the inherent attributes of Chl-CDs can lead to a secure and efficient combined cancer therapy.

KW - carbon dots

KW - chemotherapy

KW - combined cancer treatment

KW - fenton triggered reactive oxygen species production

KW - photodynamic therapy

KW - red emissive nanomaterials

UR - http://www.scopus.com/inward/record.url?scp=85182429008&partnerID=8YFLogxK

U2 - 10.1002/smll.202309283

DO - 10.1002/smll.202309283

M3 - Article

C2 - 38230862

AN - SCOPUS:85182429008

SN - 1613-6810

VL - 20

JO - Small

JF - Small

IS - 18

M1 - 2309283

ER -

Kirbas Cilingir E, Besbinar O, Giro L, Bartoli M, Hueso JL, Mintz KJ et al. Small Warriors of Nature: Novel Red Emissive Chlorophyllin Carbon Dots Harnessing Fenton-Fueled Ferroptosis for In Vitro and In Vivo Cancer Treatment. Small. 2024 May 2;20(18):2309283. doi: 10.1002/smll.202309283